ОБЗОРЫ

David H. Adams², Alberto Sanchez-Fueyo³, Didier Samuel^1,*

¹ AP-HP Hopital Paul-Brousse, Centre Hepato-Biliaire; Inserm, Research Unit 1193; Universite Paris-Sud, Villejuif F-94800, France; ² Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham and Queen Elizabeth Hospital, Edgbaston Birmingham B152TT, United Kingdom; ³ Institute of Liver Studies, MRC Centre for Transplantation, King’s College London, London SE5 9RS, United Kingdom

^* Автор, ответственный за переписку.

Tom H. Karlsen^1,2, Frank Lammert^3,4,*, Richard J. Thompson⁵

¹ Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; ² Institute of Clinical Medicine, University of Oslo, Oslo, Norway; ³ Department of Medicine II, Saarland University Medical Center, Homburg, Germany; ⁴ Saarland University, Saarbrucken, Germany; ⁵ Institute of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, King’s College London, London, United Kingdom

^* Автор, ответственный за переписку.

Christian Trautwein¹, Scott L. Friedman², Detlef Schuppan^3,4, Massimo Pinzani^5,*

¹ Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany; ² Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; ³ Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany; ⁴ Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; ⁵ Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK

Все авторы внесли равный вклад в подготовку обзора.

Ulrich Beuers^1,*, Michael Trauner², Peter Jansen¹, Raoul Poupon³

¹ Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands; ² Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria; ³ UPMC Universite Paris 06, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, AP-HP, Hopital Saint-Antoine, Service d’Hepatologie, F-75012 Paris, France

^* Автор, ответственный за переписку.

Philippe Mathurin^1,*, Ramon Bataller^2,*

¹ Service Maladie de l’Appareil Digestif and INSERM U995, Univ Lille 2, CHRU Lille, France; ² Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

^* Авторы, ответственные за переписку.

Christopher D. Byrne^1,2,*, Giovanni Targher³

¹ Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK; ² Southampton National Institute for Health Research, Biomedical Research Centre, University Hospital Southampton, UK; ³ Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy

^* Автор, ответственный за переписку.

Vlad Ratziu^1,*, Zachary Goodman², Arun Sanyal³

¹ Universite Pierre et Marie Curie, ICAN – Institute for Cardiometabolism and Nutrition, Hopital Pitie Salpetriere, Paris, France; ² Center for Liver Diseases, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA; ³ Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

Реферат

Из всех аспектов неалкогольной жировой болезни печени (НАЖБП) самое медленное развитие происходит в области лечения.

George V. Papatheodoridis^1,*, Henry Lik-Yuen Chan², Bettina E. Hansen³, Harry L.A. Janssen^3,4, Pietro Lampertico⁵

¹ Academic Department of Gastroenterology, Athens University Medical School, Laiko General Hospital, Athens, Greece; ² Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; ³ Department of Gastroenterology & Hepatology, Erasmus MC University Hospital, Rotterdam, The Netherlands; ⁴ Francis Family Liver Clinic, Toronto Western & General Hospital, Division of Gastroenterology, University of Toronto, Toronto, Canada; ⁵ 1st Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy

^* Автор, ответственный за переписку.

Ming-Ling Chang, Yun-Fan Liaw^*

Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan

^* Автор, ответственный за переписку. Адрес: Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan.

Agustin Albillos^1,2,3,*, Margaret Lario¹, Melchor Аlvarez-Mon^1,2,4

¹ Department of Medicine, Universidad de Alcala, Madrid, Spain; ² CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; ³ Service of Gastroenterology and Hepatology, Hospital Universitario Ramуn y Cajal, IRYCIS, Madrid, Spain; ⁴ Service of Immune Diseases and Oncology, Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, Spain

Реферат

Термин «иммунная дисфункция, ассоциированная с циррозом печени» относится к основным синдромным нарушениям иммунитета, иммунодефициту и системному воспалению, которые имеются при циррозе печени.