Статьи

Michael P. Manns^1,*, Ansgar W. Lohse², Diego Vergani³

¹ Hannover Medical School, Hannover, Germany; ² University Medical Centre Eppendorf, Hamburg, Germany; ³ Institute of Liver Studies, King’s College Hospital, London, United Kingdom

* Автор, ответственный за переписку.

Jaume Bosch^1,*, Roberto J. Groszmann², Vijay H. Shah³

¹ Hospital Clinic—IDIBAPS, University of Barcelona and Centro de Investigacion, Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBERehd), Barcelona, Spain; ² Yale University, School of Medicine New Haven, CT, USA; ³ Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

Ключевые слова: портальное давление, звездчатые клетки печени, синусоидальный эндотелий печени, эндотелиальная дисфункция, гипердинамический синдром, расширение сосудов брюшной полости.

Vicente Arroyo,¹ Richard Moreau,² Rajiv Jalan,³ Pere Gines,^4,* от имени авторов исследования CANONIC, проведенного EASL и Консорциумом по ХПеН

¹ Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain; ² Inserm Unite 1149, Centre de Recherche sur l’inflammation (CRI) Paris, UMR S_1149, Universite Paris Diderot, Paris, DHU UNITY, Service d’Hepatologie, Hopital Beaujon, APHP, Clichy, France; ³ Liver Failure Group, Institute for Liver and Digestive Health, Royal Free Hospital, UCL, London, United Kingdom; ⁴ Liver Unit, Hospital Clinic, University of Barcelona, Insitut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas (CIBEReHD), Instituto Reina Sofia de Investigacion en Nefrologia (IRSIN), Spain

^* Автор, ответственный за переписку.

Jordi Bruix^1,*, Kwang-Hyub Han², Gregory Gores³, Josep Maria Llovet^1,4,5, Vincenzo Mazzaferro⁶

¹ Barcelona Clinic Liver Cancer Group (BCLC), Liver Unit, IDIBAPS, CIBERehd, Hospital Clinic, Universitat de Barcelona, Catalonia, Spain; ² Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; ³ Mayo Clinic, Mayo College of Medicine, Rochester, MN, USA; ⁴ Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; ⁵ Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Catalonia, Spain; ⁶ Gastrointestinal Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS (National Cancer Institute), Milan 20133, Italy

^* Автор, ответственный за переписку.

Stuart J. Forbes^1,*, Sanjeev Gupta², Anil Dhawan³

¹ MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh EH16 4UU, United Kingdom; ² Departments of Medicine and Pathology, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Ullmann Building, Room 625, Bronx, NY 10461, United States; ³ Paediatric Liver GI and Nutrition Center and IHR/Wellcome Cell Therapy Unit, King’s College Hospital at King’s College, London SE59RS, United Kingdom

^* Автор, ответственный за переписку.

David H. Adams², Alberto Sanchez-Fueyo³, Didier Samuel^1,*

¹ AP-HP Hopital Paul-Brousse, Centre Hepato-Biliaire; Inserm, Research Unit 1193; Universite Paris-Sud, Villejuif F-94800, France; ² Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham and Queen Elizabeth Hospital, Edgbaston Birmingham B152TT, United Kingdom; ³ Institute of Liver Studies, MRC Centre for Transplantation, King’s College London, London SE5 9RS, United Kingdom

^* Автор, ответственный за переписку.

Tom H. Karlsen^1,2, Frank Lammert^3,4,*, Richard J. Thompson⁵

¹ Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; ² Institute of Clinical Medicine, University of Oslo, Oslo, Norway; ³ Department of Medicine II, Saarland University Medical Center, Homburg, Germany; ⁴ Saarland University, Saarbrucken, Germany; ⁵ Institute of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, King’s College London, London, United Kingdom

^* Автор, ответственный за переписку.

Christian Trautwein¹, Scott L. Friedman², Detlef Schuppan^3,4, Massimo Pinzani^5,*

¹ Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany; ² Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; ³ Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany; ⁴ Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; ⁵ Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK

Все авторы внесли равный вклад в подготовку обзора.

Ulrich Beuers^1,*, Michael Trauner², Peter Jansen¹, Raoul Poupon³

¹ Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands; ² Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria; ³ UPMC Universite Paris 06, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, AP-HP, Hopital Saint-Antoine, Service d’Hepatologie, F-75012 Paris, France

^* Автор, ответственный за переписку.